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KMID : 0613820110210081120
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Journal of Life Science
2011 Volume.21 No. 8 p.1120 ~ p.1126
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Anti-Oxidant and Antiinflammatory Effects of Rosa multiflora Root
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Park Gun-Hye
Lee Jin-Young
Kim Dong-Hee
Cho Young-Je
An Bong-Jeun
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Abstract
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Rosa multiflora thunberg belonging to Rosaceae is widely distributed in East Asia including Korea and Japan, and has been reported to have tormentic acid and rosamultin. To develop a new natural anti-inflammatory agent for cosmetics, we investigated the inhibitory effects of inflammation in Rosa multiflora root (R. multiflora root). The biological activity and anti-inflammatory effects were investigated by water, ethanol, methanol and acetone extracts of R. multiflora root. The measurements of polyphenol content from R. multiflora root were highest in water and acetone extracts, at 57.48 ± 0.88 ㎎/g and 67.05 ± 0.56 ㎎/g, respectively. The result of DPPH, ABTS and superoxide anion radical scavenging effects showed over 50% efficacy at 50 ㎍/㎖ in ethanol, methanol and acetone extracts. Hyaluronidase inhibition effect showed over 60% efficacy at 500 ㎍/㎖ in ethanol, methanol, and acetone extracts. Nitric oxide radical inhibition effect of R. multiflora root ethanol extracts showed over 30% efficacy at 500 ㎍/㎖. We investigated the effect of R. multiflora root extracts on nitric oxide (NO) production of inducible nitric oxide synthase (iNOS) in LPS-induced RAW 264.7 macrophage cells. The result showed that R. multiflora root extracts have an inhibitory effect on NO production and iNOS expression and also can be used as an anti-inflammatory agent. These antioxidant and anti-inflammatory effects of R. multiflora root show applicant potential application as a functional cosmetic material.
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KEYWORD
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Rosa multiflora root, antioxidant effect, anti-inflammatory, nitric oxide(NO), inducible nitric oxide synthase(iNOS)
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